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KMID : 0370219970410030345
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Yakhak Hoeji
1997 Volume.41 No. 3 p.345 ~ p.351
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Inhibition of Na+,K+-Atase, cyclicAMP Phosphodisterase and Platelet Activation by Secondary Metabolites form Marine Organisms
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박용현/Park YH
장성근/김인규/서영완/신종헌/Chang SK/Kim IK/Seo YW/Shin JH
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Abstract
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The purpose of this investigation was to determine the inhibition of Na+,K+-ATPase, cyclicAMP phophodiesterase and platelet activation by secondary metabolites isolated from marine organisms. The secondary metabolites were isolated and identified as six diterpenoids(1 : astrogorgin, 2 : ophirin, 3 : calicophirin B, 4, 5 and 6 : cladiellin) from the dichloromethane extract of Muricellajsp., four ceramides(1,2,3, and 4) from Acabaria undulata and three antharaquinones(1,2 : crysophanol, and 3 : physcion) from Urechis unicintus. The results demonstrated that diterpenoids(2,3, and 4) showed the inhibition of cyclicAMP phosphodiesterase, and ceramides(1,3, and 4) showed the inhibition of cyclicAMP phosphodiesterase and thrombin(0.1 units/ml)-induced aggregation of washed rabbit platelet, and anthrapuinones((1,2, and 3) showed the inhibition of Na+,K+-ATPase. Among the anthraquionones, 1,2-dimethoxy-3-methyl-8-hydroxy-anthraquinone(1) showed the inhibition of collagen(1.0 mcg/ml)-induced aggregation in a concenration-dependent manner with IC50 value of 42.8 mcM.
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